Response: Re: Acute Myeloid Leukemia or Myelodysplastic Syndrome Following Use of Granulocyte Colony-Stimulating Factors During Breast Cancer Adjuvant Chemotherapy

Occurrence of Secondary Acute Myeloid Leukemia in a Patient with Breast Cancer after Chemotherapy

Granulocyte-Colony Stimulating Factor (Filgrastim) Accelerates Granulocyte Recovery After Intensive Postremission Chemotherapy for Acute Myeloid Leukemia With Aziridinyl Benzoquinone and Mitoxantrone: Cancer and Leukemia

This study evaluated the effect of filgrastim (granulocyte the day after completion of the third cycle of chemotherapy. There was a marked decrease in the duration of granulocytocolony-stimulating factor [G-CSF]) on the duration of granulocytopenia and thrombocytopenia after intensive consolipenia less than 500/mL in two groups of patients receiving two different dose levels of AZQ and the same...

Granulocyte-Colony Stimulating Factor (Filgrastim) Accelerates Granulocyte Recovery After Intensive Postremission Chemotherapy for Acute Myeloid Leukemia With Aziridinyl Benzoquinone and Mitoxantrone: Cancer and Leukemia Group B Study

This study evaluated the effect of filgrastim (granulocyte the day after completion of the third cycle of chemotherapy. There was a marked decrease in the duration of granulocytocolony-stimulating factor [G-CSF]) on the duration of granulocytopenia and thrombocytopenia after intensive consolipenia less than 500/mL in two groups of patients receiving two different dose levels of AZQ and the same...

Use of colony-stimulating factors in the treatment of acute myeloid leukemia.

I N THIS ISSUE OF BLOOD, Ohno et a l l become the first to report a trial in which patients with acute myeloid leukemia (AML) received granulocyte colony-stimulating factor (G-CSF) both before and during, as well as after, chemotherapy. Fifty-eight patients in relapse or resistant to 2 courses of initial therapy (n = 50) or with untreated disease arising out of a myelodysplastic syndrome (n = 8...

Myelodysplastic Syndrome transformed to Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is also referred to non-lymphocytic leukemia in the literature. It comprises about 15% of the childhood leukemia. There are multiple subtypes of AML from M0-M7 with approximately 45% of the cases being M0-M2 and the remaining subtypes being rare. The definitive diagnosis relies on bone marrow biopsy showing bone marrow infiltration with leukemic cells. We describe a...